Skip to main content

8-Hydroxy-2′-Deoxyguanosine

Meaning

8-Hydroxy-2′-Deoxyguanosine, commonly abbreviated as 8-OHdG, is a specific modified nucleoside and a key biomarker for measuring oxidative DNA damage within the body. This compound is essentially a molecular signature indicating the degree of stress that reactive oxygen species have placed upon the cellular genetic material. Its presence in elevated levels suggests a persistent state of cellular oxidative stress, which is a fundamental process underlying aging and chronic disease pathogenesis. The measurement of this metabolite is crucial in clinical research to quantify the extent of damage to the foundational blueprint of life.