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5-ARI Efficacy

Meaning

The clinical measure of a 5-alpha reductase inhibitor’s effectiveness in reducing dihydrotestosterone (DHT) levels to achieve a desired therapeutic outcome. This metric quantifies the success rate of drugs like finasteride and dutasteride in managing androgen-dependent conditions. Efficacy is often assessed by monitoring prostate volume reduction in benign prostatic hyperplasia (BPH) or by evaluating hair count and density in androgenetic alopecia. It is a critical parameter for prescribers to weigh the benefit against the risk of potential adverse effects. The therapeutic goal is to diminish the potent androgenic signaling mediated by DHT in target tissues.