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5-Alpha Reductase Variants

Meaning

These refer to the distinct isoforms of the 5-alpha reductase enzyme, which is a critical enzyme responsible for converting the androgen testosterone into the more potent dihydrotestosterone (DHT). The two primary forms, Type 1 and Type 2, exhibit differential tissue distribution and functional activity within the human body. Understanding these enzyme variants is essential for targeting hormonal pathways involved in conditions like androgenic alopecia, benign prostatic hyperplasia, and certain endocrine disorders. Genetic polymorphisms can further influence the activity and expression of these isoforms, leading to individualized clinical presentations and treatment responses.