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5αr2 Isoenzyme

Meaning

The Type 2 isoform of the 5-alpha reductase enzyme, which is highly concentrated in specific androgen-sensitive tissues such as the prostate, male genitalia, and hair follicles. This enzyme is the primary catalyst for converting circulating testosterone into the potent androgen dihydrotestosterone (DHT) in these key areas. Its role is clinically significant due to its association with conditions like benign prostatic hyperplasia and male pattern baldness.