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5α-Reductase Activity

Meaning

This term refers to the enzymatic process driven by the 5α-reductase enzyme, which catalyzes the conversion of testosterone into the significantly more potent androgen, dihydrotestosterone (DHT). The activity level of this enzyme dictates the local concentration of DHT in various target tissues, profoundly influencing androgen-dependent biological effects. Understanding this activity is crucial for managing conditions like androgenic alopecia and benign prostatic hyperplasia. Clinical practice often involves assessing and modulating this enzyme’s function to achieve hormonal balance and address specific health concerns.