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40-Amino-Acid Rule

Meaning

The 40-Amino-Acid Rule, in a general biochemical context, refers to a structural threshold often considered significant for the functional properties of peptides. This length demarcates smaller, typically rapidly acting neuropeptides or signaling molecules from larger, more complex protein structures. Understanding this size constraint is relevant when considering the pharmacokinetics of therapeutic peptide hormones. The precise biological significance often depends on the specific sequence and folding characteristics of the molecule.