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4-Point Cortisol Test

Meaning

A non-invasive diagnostic tool that measures cortisol levels at four distinct points throughout a 24-hour cycle. This test provides a comprehensive assessment of the Hypothalamic-Pituitary-Adrenal (HPA) axis function, moving beyond a single snapshot measurement. It is critical for evaluating the body’s physiological stress response and the circadian rhythmicity of this primary glucocorticoid hormone. Clinicians utilize this data to identify subtle patterns of adrenal dysfunction, such as an attenuated awakening response or hypercortisolism, which profoundly impact overall hormonal balance and systemic well-being.