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2-OH: 16α-OH Ratio

Meaning

This ratio represents the balance between two primary estrogen metabolites, 2-hydroxyestrone (2-OH) and 16-alpha-hydroxyestrone (16α-OH). Clinically, this measurement provides insight into the preferred pathway of estrogen metabolism within the body, which is a critical aspect of hormonal health. A higher ratio generally suggests a more favorable metabolic profile, favoring the less proliferative 2-OH pathway. Understanding this balance is essential for assessing an individual’s detoxification capacity and long-term wellness trajectory.