Skip to main content

2-Methoxyestradiol

Meaning

2-Methoxyestradiol, often abbreviated as 2-ME2, is an endogenous, naturally occurring metabolite derived from the primary estrogen hormone, estradiol. This compound is classified as a catechol estrogen, formed through the methylation of 2-hydroxyestradiol by the Catechol-O-methyltransferase enzyme. While it possesses significantly lower affinity for the classic estrogen receptors compared to its parent hormone, its distinct biological profile has positioned it as a molecule of considerable clinical interest. It functions not as a typical estrogen, but as a compound with unique antiproliferative and anti-inflammatory properties.