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2-Hydroxy-Estrone (2-OH)

Meaning

2-Hydroxy-Estrone, or 2-OH, is a primary and generally considered protective metabolite derived from the breakdown of the estrogen Estrone (E1) in the liver. This particular compound is distinguished by its relatively low affinity for the estrogen receptor, meaning it exerts minimal proliferative effects on estrogen-sensitive tissues. Clinically, a favorable ratio of 2-OH Estrone to other estrogen metabolites is a critical indicator of a healthy estrogen detoxification pathway, supporting long-term hormonal balance. Assessing this metabolite provides actionable insight into the body’s ability to safely process and clear estrogens.