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2-Hydroxy-Estrone

Meaning

2-Hydroxy-Estrone (2-OHE1) is a principal, non-proliferative metabolite of the estrogen hormone estrone, formed during the initial phase of liver detoxification. This specific catechol estrogen is often clinically characterized as a “good” estrogen due to its significantly weaker binding affinity to the Estrogen Receptor (ER) compared to parent estrogens. Monitoring the ratio of 2-OHE1 to other metabolites, such as 16-alpha-hydroxyestrone, provides critical insight into an individual’s unique estrogen metabolism profile. Maintaining a favorable profile is considered an important strategy for promoting long-term hormonal health and wellness. This metabolite represents a key pathway for safe and efficient estradiol breakdown.