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2: 16 OHE Ratio

Meaning

The 2: 16 OHE Ratio is a clinically utilized measure representing the relative proportion of two primary estrogen metabolites: 2-hydroxyestrone (2-OHE1) to 16-alpha-hydroxyestrone (16-OHE1). This ratio serves as a biochemical marker reflecting the preferential pathway of estrogen breakdown in the body, indicating a metabolic tendency toward either protective or proliferative estrogen activity. A higher ratio is generally viewed as favorable, suggesting a metabolic environment that promotes the less potent, less proliferative 2-OHE1 pathway. The assessment provides crucial insight into the balance of estrogen detoxification, a process profoundly relevant to hormonal health and wellness.