Skip to main content

2: 16α-Hydroxyestrone Ratio

Meaning

This ratio is a clinical biomarker reflecting the balance between two primary estrogen metabolites: 2-hydroxyestrone (2-OHE1) and 16α-hydroxyestrone (16α-OHE1). A higher ratio is generally considered favorable, indicating a greater production of the less proliferative 2-OHE1 metabolite. Clinicians utilize this specific measurement in the assessment of estrogen metabolism pathways, particularly when evaluating potential risks associated with estrogen-sensitive tissues. Monitoring this balance provides crucial insight into how the body is detoxifying and processing its endogenous estrogens.