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17β-Hydroxysteroid Dehydrogenase 2

Meaning

17β-Hydroxysteroid Dehydrogenase 2 (17β-HSD2) is a critical enzyme in the human body responsible for regulating the local concentrations of potent sex steroids. This enzyme primarily functions as a catalyst for the oxidative conversion of active 17β-hydroxysteroids into their less active 17-keto counterparts. Clinically, it serves as a key modulator of hormonal balance within target tissues, profoundly impacting androgen and estrogen action. Understanding its activity is essential for assessing local hormonal environments.