Question 1

What is the Meaning of 17β-Hydroxysteroid Dehydrogenase 2?

Accepted Answer

17β-Hydroxysteroid Dehydrogenase 2 (17β-HSD2) is an enzyme that inactivates potent sex steroids. It converts 17β-estradiol to estrone and testosterone to androstenedione, rendering them less biologically active. This enzyme regulates local hormone concentrations within various tissues, modulating their cellular effects.

Question 2

What is the Context of 17β-Hydroxysteroid Dehydrogenase 2?

Accepted Answer

This enzyme functions intracellularly across human tissues, including endometrium, placenta, liver, prostate, and breast. As a key component of the steroid hormone metabolic pathway, it plays an integral role within the endocrine system. 17β-HSD2 activity is crucial for maintaining precise balance of active steroid hormones at a tissue-specific level.

Question 3

What is the Significance of 17β-Hydroxysteroid Dehydrogenase 2?

Accepted Answer

The clinical importance of 17β-HSD2 stems from its influence on estrogen and androgen activity in target tissues, impacting health outcomes. Dysregulation can contribute to hormone-sensitive conditions such as endometriosis, benign prostatic hyperplasia, or certain breast and endometrial cancers. Understanding its role aids clinicians in interpreting symptoms and formulating therapeutic strategies.

Question 4

What is the Mechanism of 17β-Hydroxysteroid Dehydrogenase 2?

Accepted Answer

17β-HSD2 catalyzes the NAD(P)+-dependent oxidation of the 17β-hydroxyl group of specific steroids. This reaction converts potent 17β-hydroxysteroids, like estradiol and testosterone, into their 17-keto forms, estrone and androstenedione, which have reduced biological activity. This enzymatic process diminishes hormone signaling at the cellular receptor level.

Question 5

What is the Application of 17β-Hydroxysteroid Dehydrogenase 2?

Accepted Answer

In clinical practice, 17β-HSD2 activity is relevant for protecting tissues from excessive estrogenic stimulation by limiting cellular proliferation. Therapeutic approaches for hormone-dependent disorders may involve modulating 17β-HSD2 activity to alter local hormone concentrations. Optimal 17β-HSD2 function contributes to hormonal equilibrium.

Question 6

What is the Metric of 17β-Hydroxysteroid Dehydrogenase 2?

Accepted Answer

Direct measurement of 17β-HSD2 enzyme activity is primarily research-based. Clinically, assessment relies on indirect markers. Monitoring circulating levels of its substrates, like estradiol and testosterone, and their less active products, estrone and androstenedione, provides insights into overall steroid metabolism.

Question 7

What is the Risk of 17β-Hydroxysteroid Dehydrogenase 2?

Accepted Answer

Alterations in 17β-HSD2 activity carry distinct clinical risks. Overactive enzyme reduces beneficial estrogenic effects, contributing to osteoporosis or mood disturbances. Conversely, deficient activity leads to undesirable accumulation of potent sex steroids, promoting uncontrolled cellular proliferation in endometrial hyperplasia, certain breast cancers, or benign prostatic hyperplasia.

17β-Hydroxysteroid Dehydrogenase 2

Meaning

Context

Significance

Mechanism

Application

Metric

Risk

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