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11-Oxygenated Androgens

Meaning

11-Oxygenated Androgens are a distinct class of steroid hormones, considered weak androgens, characterized by the presence of an oxygen atom or hydroxyl group at the 11th carbon position of the steroid nucleus. These compounds, which include 11-hydroxytestosterone and 11-ketotestosterone, are primarily synthesized by the adrenal glands. Recent endocrine research highlights their significant, often overlooked, contribution to the total circulating androgen pool, especially in conditions involving adrenal hyperandrogenism. Understanding these metabolites is essential for a precise clinical assessment of overall androgen status beyond just classic testosterone.