Question 1

What is the Meaning of 11-beta-HSD2?

Accepted Answer

11-beta-hydroxysteroid dehydrogenase type 2 (11-beta-HSD2) is an enzyme crucial for regulating the local concentration of active glucocorticoids, particularly cortisol, within mineralocorticoid-sensitive tissues. It functions as a critical biochemical shield, preventing the powerful effects of cortisol from inappropriately activating the aldosterone receptor. Maintaining the precise activity of this enzyme is essential for preserving fluid and electrolyte balance in the body.

Question 2

What is the Origin of 11-beta-HSD2?

Accepted Answer

This term is derived from its precise enzymatic function: it is a dehydrogenase that acts on the 11-beta-hydroxyl group of the steroid structure. The 'type 2' designation distinguishes it from the type 1 isoform, which primarily performs the reverse, activating reaction. This specific enzymatic system represents a fundamental regulatory checkpoint within the broader adrenal steroid hormone pathway.

Question 3

What is the Mechanism of 11-beta-HSD2?

Accepted Answer

The enzyme catalyzes the rapid, irreversible conversion of active cortisol into its inactive metabolite, cortisone. This metabolic inactivation ensures that the mineralocorticoid receptor, found in the kidney and colon, remains selectively responsive to aldosterone, the body's true mineralocorticoid. Dysfunction or inhibition of 11-beta-HSD2 can lead to hypertension and hypokalemia, mimicking an excess of aldosterone due to unregulated cortisol action.

11-beta-HSD2

Meaning

Origin

Mechanism

How Do Electrolyte Imbalances Influence Adrenal Gland Function?

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