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11-beta-HSD1

Meaning

11-beta-HSD1 is an essential enzyme that locally regulates the concentration of active glucocorticoids, primarily cortisol, within specific tissues. This enzyme acts as a reductase, converting the inactive storage form, cortisone, into the biologically potent hormone, cortisol, which profoundly impacts local metabolic and cognitive functions. This localized control is a critical determinant of glucocorticoid signaling intensity in metabolic tissues like fat and liver. Its activity level is often implicated in the development of metabolic syndrome and chronic stress-related pathology.