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11β-HSD1

Meaning

11-beta Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) is an enzyme that serves as a crucial regulator of local glucocorticoid action within specific tissues. This enzyme is predominantly responsible for converting the inactive cortisone into the active stress hormone cortisol, particularly in metabolic tissues like the liver, adipose tissue, and central nervous system. Its localized activity helps modulate tissue-specific glucocorticoid exposure, which is distinct from the systemic cortisol levels measured in blood. Dysregulation of 11β-HSD1 activity is clinically associated with metabolic syndrome, visceral adiposity, and insulin resistance, underscoring its importance in hormonal health.