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Β-Glucuronidase

Meaning

Beta-Glucuronidase (β-Glucuronidase) is a lysosomal enzyme, a type of hydrolase, that plays a critical role in the body’s detoxification and excretion pathways by cleaving glucuronic acid residues from various glucuronide conjugates. In the context of hormonal health, this enzyme is particularly significant because it can deconjugate and reactivate steroid hormones, such as estrogens and androgens, that the liver has specifically tagged for excretion. High activity of this enzyme, often influenced by an imbalanced gut microbiota, can lead to the reabsorption of these hormones, potentially contributing to elevated circulating levels and systemic hormonal imbalance.