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Α-Klotho

Meaning

Alpha-Klotho (α-Klotho) is a transmembrane protein primarily expressed in the kidneys, parathyroid glands, and choroid plexus of the brain, known clinically as a potent anti-aging and longevity factor. This protein exists in both membrane-bound and soluble forms, functioning as a co-receptor for fibroblast growth factor 23 (FGF23) to regulate phosphate and vitamin D metabolism. Critically, its systemic concentration is inversely correlated with chronological age and the severity of age-related disease.